Tissues and extracellular matrix (ECM) components possess distinct mechanical properties which reflect and direct local cellular development and behavior. The sensitivity of cells to mechanical influences can be exploited in a number of ways to guide cell responses and understand the impact and interplay of mechanosensitive pathophysiological changes. We showed in Phase 2 that particles adsorbed to a surface can be removed by cells in a highly localized manner and that the removability of these particles was found to be dependent on particle physico-chemical properties such as size and stiffness as well as cell-type characteristics. We also observed that inflammatory stimuli can modulate the interaction of cells with nanoparticles, which opens many possibilities to enhance the performance of nanobiomedicines through greater targeting specificity and stability. Building on these findings, In Phase 3, our aim is to further develop dynamic and disease-relevant responsive materials to advance our understanding of tissue dynamics and particle interactions.