Module 3: Responsive bio-interfaces and surfaces

F/D

The rapid expansion of nanoscience has resulted in many smart (nano)materials, which are increasingly used for biomedical purposes. The transfer of basic research into commercially viable products has however been proven to be difficult because the knowledge about their fundamental biological interactions remains scarce. All research groups in Module 3 focus on the design, fabrication and characterization of innovative, sophisticated nanomaterials / substrate composites with nanomaterials, and their bio-interfacing through biological fluids, cell culture and cancer models. The goal of the proposed studies is to explore the mechanisms of the interactions of bio-inspired, responsive (nano)materials including composites with biological interfaces in order to provide a knowledge base for further applications in the biomedical field, as for example the early detection and treatment of cancer, and the growth of (lung) tissue on responsive membranes.

Research projects

  • Novel antiviral supramolecular materials
  • NanoRoomba®:Cellular uptake and durotaxis on "soft and rigid" nanoparticles carpet
  • Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake
  • Self-assembly of DNA- or RNA-triggered ion channels for targeted cell killing and nanopore sensing
  • Trapping cancer cells with self-assembling bio-molecules
  • Fluorescent nanodiamonds as quantum bio-molecular probes for cell imaging and sensing
  • Characterization of nanoparticle-membrane interactions via molecular dynamics simulations
  • Steering tissue morphogenesis via programmable microgel assemblies

Project leaders:

Novel antiviral supramolecular materials

NanoRoomba®:Cellular uptake and durotaxis on "soft and rigid" nanoparticles carpet

Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

Self-assembly of DNA- or RNA-triggered ion channels for targeted cell killing and nanopore sensing

Trapping cancer cells with self-assembling bio-molecules

Fluorescent nanodiamonds as quantum bio-molecular probes for cell imaging and sensing

Characterization of nanoparticle-membrane interactions via molecular dynamics simulations

Steering tissue morphogenesis via programmable microgel assemblies

The National Centers of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation
Hosted by: Adolphe Merkle Institute - Chemin des Verdiers 4 - CH-1700 Fribourg - Phone +41 26 300 9266