Module 3: Interactions with living cells

F/D

The rapid expansion of nanoscience has resulted in many smart (nano)materials, which are increasingly used for biomedical purposes. The transfer of basic research into commercially viable products has however been proven to be difficult because the knowledge about their fundamental biological interactions remains scarce. All research groups in Module 3 focus on the design, fabrication and characterization of innovative, sophisticated nanomaterials / substrate composites with nanomaterials, and their bio-interfacing through biological fluids, cell culture and cancer models. The goal of the proposed studies is to explore the mechanisms of the interactions of bio-inspired, responsive (nano)materials including composites with biological interfaces in order to provide a knowledge base for further applications in the biomedical field, as for example the early detection and treatment of cancer, and the growth of (lung) tissue on responsive membranes.

Research projects

  • Sensoresponsive nanoelements to detect individual cancer cells.
  • Evolving nanoparticles.
  • Magneto-responsive cell culture substrates that can be modulated in situ.
  • Intelligent nanomaterials to reveal and to control their behavior in complex media, at the biointerface and in cells.
  • Targeted cell killing by self-assembly on DNA- or RNA-triggered ion channel.
  • Controlled activation of cancer-associated immune cells by stimuli-responsive nanoparticles.

Goals

  • Development of sensoresponsive nanoparticles that are capable of dynamic self-assembly through amplification cascades allowing sensitive detection and elimination of individual cancer cells.
  • Creation of patchy particles that are able to complex small molecules and peptides and, in doing so, can dynamically change their properties.
  • Design and modulation of new types of stimuli-responsive substrates for different cell types to study dynamic cellular responses using hybrid magnetoresponsive materials in situ.
  • Fundamental understanding of the behavior of nanomaterials in biological fluids as well as the nanomaterial interaction with cells, including immune and cancer cells.

Project leaders:

Sensoresponsive nanoelements to detect individual cancer cells

Evolving nanoparticles

Magneto-responsive cell culture substrates that can be modulated in situ

Intelligent nanomaterials to reveal and to control their behavior in complex media, at the biointerface and in cells

Targeted cell killing by self-assembly on DNA- or RNA-triggered ion channel

Controlled activation of cancer-associated immune cells by stimuli-responsive nanoparticles

The National Centers of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation
Hosted by: Adolphe Merkle Institute - Chemin des Verdiers 4 - CH-1700 Fribourg - Phone +41 26 300 9266